Study of the addictive potential of modafinil in naive and cocaine-experienced rats.
Deroche-Gamonet V, Darnaudery M,
Bruins-Slot L, Piat F, Le Moal M, Piazza PV.
Laboratoire de Psychobiologie des Comportements Adaptatifs, Domaine de Carreire, Rue Camille Saint-Saens,
33077 Bordeaux, France.
Psychopharmacology (Berl) 2002 Jun;161(4):387-95
RATIONALE: Modafinil is a drug that promotes wakefulness and, as such, is used to treat hypersomnia and narcolepsy. Preclinical and clinical studies suggest that modafinil could possess weak reinforcing effects in drug-experienced subjects. However, its abuse potential in drug-naive healthy individuals is still totally uninvestigated, despite the fact that availability of modafinil has recently increased.
OBJECTIVES: The purpose of our study was to investigate the potential addictive properties of modafinil by testing its reinforcing effects in naive rats. The interactions of modafinil with the reinforcing effects of cocaine were also tested.
METHODS: First, using i.v. self-administration and place conditioning tests, we studied the reinforcing and rewarding effects of a large range of doses of modafinil in naive rats. Second, we tested the influence of modafinil on reinforcing and incentive effects of cocaine in rats trained for cocaine self-administration. The effects of modafinil were compared with those of amphetamine and haloperidol.
RESULTS: Modafinil did not produce reinforcing or rewarding effects and did not modify the effects of cocaine.
CONCLUSIONS: Our results suggest that modafinil does not possess an addictive potential in naive individuals. Furthermore, it would be behaviorally distinct from classical central nervous system stimulants which are known to alter cocaine-induced effects. However, as shown previously in nonhuman primates and in humans, modafinil could possibly have reinforcing effects in cocaine-experienced individuals.
Home | to
1. Modafinil augmentation
of antidepressant treatment
2. Modafinil children
with attention-deficit/hyperactivity disorder
3. Modafinil in
efficacy in narcolepsy
5. Modafinil narcolepsy:
symptoms and management
6. Modafinil successful
treatment of hypersomnia & narcolepsy
drug of choice for narcolepsy
in the treatment of narcolepsy
effect on narcolepsy
a narcolepsy study
switching from narcolepsy drugs to modafinil
and naps as counter measures in sleep
as a treatment for excessive daytime sleepiness
use in a sleep deprivation experiment
15. Modafinil excessive
sleepiness in Parkinson's disease
16. Modafinil the
unique properties of a new stimulant
17. Modafinil for
sustaining the alertness of helicopter pilots
18. Modafinil dosage
treatment of alcoholic organic brain syndrome
effect on melatonin, cortisol, and growth hormone
in obstructive sleep apnea-hypopnea syndrome
vs dextroamphetamine in treatment of adult ADHD
dopaminergic transmission mediates CNS stimulants
for daytime sleepiness in sleep apnea
treatment of residual excessive daytime
amplification of cortical serotonin release
27. Modafinil for
the treatment of multiple sclerosis