Problems associated with switch to
modafinil - a novel alerting agent in narcolepsy
Guilleminault C, Aftab FA, Karadeniz D,
Philip P, Leger D
Stanford Sleep Disorders Clinic
and Research Center, CA 94605, USA.
Eur J Neurol 2000 Jul; 7(4):381-4
Modafinil is a novel medication recently
approved for the treatment of narcolepsy and idiopathic hypersomnia.
Commonly, patients had already been prescribed medications for their
syndrome. This report outlines difficulties encountered in the
clinical practice of switching patients to modafinil. Naive subjects
accepted modafinil best. Subjects withdrawn from amphetamine had the
most problems and failure to withdraw. Venlafaxine hydrochloride
combined well with modafinil to control cataplectic attacks. Usage of
a progressive withdrawal protocol may ease the difficulties observed.
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