Effects of modafinil
on
symptomatology of human narcolepsy.
Caldwell JA, Caldwell JL, Smythe NK, Hall KK
Centre d'etude du sommeil,
Hopital du Sacre-Coeur,
Montreal, Quebec, Canada.
Clin Neuropharmacol 1993 Feb;16(1):46-53
ABSTRACT
We studied the effects of
modafinil, a putative central alpha-1 agonist, on the excessive daytime
sleepiness (EDS) of 10 narcoleptic patients while using a double-blind design
and objective measurements of vigilance. There were two treatment periods, in
which either modafinil or placebo was used; each lasted four weeks and was
preceded by a 2-week "run-in" period and separated by a 2-week
"wash-out" period. The effects of treatment on EDS were evaluated by
daily home questionnaires and a psychomotor performance test, the Four Choice
Reaction Time Test (FCRTT). Modafinil reduced the daily number of
sleep attacks significantly, and markedly improved performances
during the FCRTT. Results of this study suggest that modafinil is effective in
treating EDS in narcolepsy, and that noradrenergic mechanisms could be
involved in the physiopathology of EDS in that disorder.
1. Modafinil augmentation
of antidepressant treatment
2. Modafinil children
with attention-deficit/hyperactivity disorder
3. Modafinil in
fibromyalgia treatment
4. Modafinil
efficacy in narcolepsy
5. Modafinil narcolepsy:
symptoms and management
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil
drug of choice for narcolepsy
8. Modafinil
in the treatment of
narcolepsy
9. Modafinil
effect on narcolepsy
10. Modafinil
a narcolepsy study
11. Modafinil
switching from narcolepsy drugs to modafinil
12. Modafinil
and naps as counter measures in sleep deprivation
13. Modafinil
as a treatment for excessive daytime sleepiness
14. Modafinil
use in a sleep deprivation experiment
15. Modafinil excessive sleepiness in Parkinson's disease
16. Modafinil the
unique properties of a new stimulant
17. Modafinil for
sustaining the alertness of helicopter pilots
18. Modafinil dosage
and safety
19. Modafinil
treatment of alcoholic organic brain syndrome
20. Modafinil
effect on melatonin, cortisol, and growth hormone
21. Modafinil
in obstructive sleep apnea-hypopnea syndrome
22. Modafinil
vs dextroamphetamine in treatment of adult ADHD
23. Modafinil
dopaminergic transmission mediates CNS stimulants
24. Modafinil
for daytime sleepiness in sleep apnea
25. Modafinil
treatment of residual excessive daytime sleepiness
26. Modafinil
amplification of cortical serotonin release
27. Modafinil for the treatment of
multiple sclerosis
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