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Modafinil in diurnal sleepiness. 
A study of 123 patients.

Laffont F, Mayer G, Minz M.

Unite de Sommeil, 
Explorations Fonctionnelles Neurologiques, 
CHU Pitie-Salpetriere, Paris, France.
Sleep 1994 Dec;17(8 Suppl):S113-5


The efficacy of modafinil, a psychostimulant drug acting on postsynaptic alpha-1 adrenergic receptors, as a treatment for excessive daytime sleepiness was studied in 123 patients. Subjects included 94 narcoleptic patients (76 with cataplexy), 23 hypersomnia patients and 6 patients with disrupted nocturnal sleep (DNS) and excessive daytime sleepiness (EDS). Clinical efficacy of the treatment on each symptom (EDS, cataplexy and DNS) was evaluated on a four-point scale from excellent to absent. The effectiveness of modafinil as a treatment for EDS was excellent in 17% of all patients, good in 63%, fair in 17% and absent in 3%. The incidence of side effects was rather low (14 of 123 patients) and most of them disappeared (11 patients) when doses were reduced.

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