Interest of modafinil, a new
psychostimulant, during a sixty-hour sleep deprivation experiment.
Lagarde D, Batejat D, Van Beers P, Sarafian D, Pradella S.
Institut de Medecine
Aerospatiale (Imassa-Cerma),
Departement Sciences Cognitives et Ergonomie,
Bretigny-sur-Orge, France.
Fundam Clin Pharmacol 1995;9(3):271-9
ABSTRACT
Modafinil, a new psychostimulant,
was evaluated in eight healthy volunteers subjected to 60 hours of sleep
deprivation. During continued wakefulness, vigilance was evaluated by
self-assessment questionnaires, analogue visual scales, multiple sleep latency
tests (MSLT), sleep logs, and continuous ambulatory electroencephalographic
recordings (EEG). Modafinil (200 mg) or a placebo was given every 8 hours for
three days; the sessions were separated by a 15 day wash out period. Results
indicated a satisfactory level of vigilance, both subjective and objective,
after the administration of modafinil, characterised by the quasi total
absence of microsleep episodes which gradually occurred under placebo
conditions. The confirmed wakening potency of modafinil makes this substance
suitable for therapeutic use in patients with sleep disorders such as
Gelineau's syndrome and hypersomnia.
|
Home | to
Order |
1. Modafinil augmentation
of antidepressant treatment
2. Modafinil children
with attention-deficit/hyperactivity disorder
3. Modafinil in
fibromyalgia treatment
4. Modafinil
efficacy in narcolepsy
5. Modafinil narcolepsy:
symptoms and management
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil
drug of choice for narcolepsy
8. Modafinil
in the treatment of
narcolepsy
9. Modafinil
effect on narcolepsy
10. Modafinil
a narcolepsy study
11. Modafinil
switching from narcolepsy drugs to modafinil
12. Modafinil
and naps as counter measures in sleep deprivation
13. Modafinil
as a treatment for excessive daytime sleepiness
14. Modafinil
use in a sleep deprivation experiment
15. Modafinil excessive sleepiness in Parkinson's disease
16. Modafinil the
unique properties of a new stimulant
17. Modafinil for
sustaining the alertness of helicopter pilots
18. Modafinil dosage
and safety
19. Modafinil
treatment of alcoholic organic brain syndrome
20. Modafinil
effect on melatonin, cortisol, and growth hormone
21. Modafinil
in obstructive sleep apnea-hypopnea syndrome
22. Modafinil
vs dextroamphetamine in treatment of adult ADHD
23. Modafinil
dopaminergic transmission mediates CNS stimulants
24. Modafinil
for daytime sleepiness in sleep apnea
25. Modafinil
treatment of residual excessive daytime sleepiness
26. Modafinil
amplification of cortical serotonin release
27. Modafinil for the treatment of
multiple sclerosis
Home | Order
