|
Modafinil in diurnal sleepiness.
A study of 123 patients.
Laffont F, Mayer G, Minz M.
Unite de Sommeil,
Explorations Fonctionnelles Neurologiques,
CHU Pitie-Salpetriere, Paris, France.
Sleep 1994 Dec;17(8 Suppl):S113-5
ABSTRACT
The efficacy of modafinil, a psychostimulant drug acting on
postsynaptic alpha-1 adrenergic receptors, as a treatment for excessive
daytime sleepiness was studied in 123 patients. Subjects included 94
narcoleptic patients (76 with cataplexy), 23 hypersomnia patients and 6
patients with disrupted nocturnal sleep (DNS) and excessive daytime sleepiness
(EDS). Clinical efficacy of the treatment on each symptom (EDS, cataplexy and
DNS) was evaluated on a four-point scale from excellent to absent. The
effectiveness of modafinil as a treatment for EDS was excellent in 17% of all
patients, good in 63%, fair in 17% and absent in 3%. The incidence of side
effects was rather low (14 of 123 patients) and most of them disappeared (11
patients) when doses were reduced.
Home | Order
1. Modafinil augmentation
of antidepressant treatment
2. Modafinil children
with attention-deficit/hyperactivity disorder
3. Modafinil in
fibromyalgia treatment
4. Modafinil
efficacy in narcolepsy
5. Modafinil narcolepsy:
symptoms and management
6. Modafinil successful
treatment of hypersomnia & narcolepsy
7. Modafinil
drug of choice for narcolepsy
8. Modafinil
in the treatment of
narcolepsy
9. Modafinil
effect on narcolepsy
10. Modafinil
a narcolepsy study
11. Modafinil
switching from narcolepsy drugs to modafinil
12. Modafinil
and naps as counter measures in sleep deprivation
13. Modafinil
as a treatment for excessive daytime sleepiness
14. Modafinil
use in a sleep deprivation experiment
15. Modafinil excessive sleepiness in Parkinson's disease
16. Modafinil the
unique properties of a new stimulant
17. Modafinil for
sustaining the alertness of helicopter pilots
18. Modafinil dosage
and safety
19. Modafinil
treatment of alcoholic organic brain syndrome
20. Modafinil
effect on melatonin, cortisol, and growth hormone
21. Modafinil
in obstructive sleep apnea-hypopnea syndrome
22. Modafinil
vs dextroamphetamine in treatment of adult ADHD
23. Modafinil
dopaminergic transmission mediates CNS stimulants
24. Modafinil
for daytime sleepiness in sleep apnea
25. Modafinil
treatment of residual excessive daytime sleepiness
26. Modafinil
amplification of cortical serotonin release
27. Modafinil for the treatment of
multiple sclerosis
|